THE BEST SIDE OF TRASTUZUMAB PACKAGE INSERT

The phosphorylated HER3 presents docking sites for p85 subunit of PI3K. The completely activated PI3K sophisticated is generated by binding of p110 subunit of PI3K to p85 which is able to generate PIP3 by way of phosphorylating the PIP2. AKT binds to PIP3 and is also phosphorylated by PDK1 and mTORC2. Phosphorylation of AKT at both threonine and se